Evidence-Based decision making is based on a good question. A "well-built" question should include four parts, referred to as PICO that identify the patient problem or population (P), intervention (I), comparison (C) and outcome(s) (O). (Sackett DL, 1997. Evidence-based medicine: How to practice and teach EBM),
Definition of EBM
Evidence-based medicine (EBM) is the integration of best research evidence with clinical expertise and patient values.
Definition of Best Research Evidence
Clinically relevant research, often from the basic sciences of medicine, but especially from patient centered clinical research into the accuracy and precision of diagnostic tests.
Definition of Clinical Expertise
The ability to use clinical skills and past experience to rapidly identify each patient's unique health state and diagnosis, their individual risks and benefits of potential interventions, and their personal values and expectations.
Definition of Patient Values
The unique preferences, concerns and expectations each patient brings to a clinical encounter and which must be integrated into clinical decisions if they are to serve the patient.