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Systematic Review Guide

This guide will help you navigate how to create a systematic review.

Predefining Objectives

  • Develop a clearly defined and answerable clinical question. 

Evidence-based practice:

Patient population (Problem to be addressed) Who are the patients?

Example: Children aged 3-10 y/o, diagnosed with chicken pox

Intervention (Exposure) What intervention will be delivered?

Example: Use of a specific new drug at a specific dose by a specific mode of administration

Comparison (Control, Placebo, Standard Care) What is the intervention compared with?

Example: Use of the present drug in standard conditions

Outcomes (There are, typically, a multitude of outcome tools available for different clinical populations, each having strengths and weaknesses.) What are the outcome(s) of interest? How are they measured?

Examples: Comparative relief of symptoms A, B, C; results of observations D, E, F; or test results G, H


Riva, J. J., Malik, K. M., Burnie, S. J., Endicott, A. R., & Busse, J. W. (2012). What is your research question? An introduction to the PICOT format for clinicians. The Journal of the Canadian Chiropractic Association56(3), 167–171.

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